Growth hormone-releasing hormone: Extrapituitary effects in physiology and pathology

摘要: Growth Hormone-Releasing Hormone (GHRH) is secreted by the hypothalamus and regulates release of growth hormone from anterior pituitary gland. In addition to its endocrine role, this peptide has been shown act as a factor in diverse malignancies. Recent studies indicate that GHRH also regulator several important physiological processes. These processes which include regulation metabolism reactive oxygen nitrogen species are similarly enhanced agonists. contrast, antagonists can counteract effects GHRH. agonists have contribute recovery heart tissue after myocardial infarction promote survival proliferation pancreatic islets transplantation into diabetic animals.