Genetic variations in esophageal cancer risk and prognosis.

作者: Winson Y. Cheung , Geoffrey Liu

DOI: 10.1016/J.GTC.2009.01.009

关键词:

摘要: Investigations into inherited genetic variations in the DNA code (known as polymorphisms) field of oncology have provided preliminary support for an association with cancer risks and outcomes. Early studies highlighted several genes this potential predictive prognostic power. However, these had methodological limitations produced inconsistent results, making impractical yet routine evaluation such polymorphisms general clinical practice. Continued research area is essential if we are to be able soon use better select patients targeted anticancer interventions. This review discusses role their esophageal risk prognosis. The article also highlights future directions new, emerging molecular epidemiology.

参考文章(116)
Ahmed Abbas, Karine Delvinquière, Mathilde Lechevrel, Pierre Lebailly, Pascal Gauduchon, Guy Launoy, François Sichel, GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: Different pattern of squamous cell carcinoma and adenocarcinoma World Journal of Gastroenterology. ,vol. 10, pp. 3389- 3393 ,(2004) , 10.3748/WJG.V10.I23.3389
M Tomka, K Tomkova, V Zajac, Contribution of p53, p63, and p73 to the developmental diseases and cancer. Neoplasma. ,vol. 55, pp. 177- 181 ,(2008)
Venüs Ümmiye Onay, Laurent Briollais, Julia A Knight, Ellen Shi, Yuanyuan Wang, Sean Wells, Hong Li, Isaac Rajendram, Irene L Andrulis, Hilmi Ozcelik, SNP-SNP interactions in breast cancer susceptibility BMC Cancer. ,vol. 6, pp. 114- 114 ,(2006) , 10.1186/1471-2407-6-114
Chia-Fang Wu, Deng-Chyang Wu, Hon-Ki Hsu, Ein-Long Kao, Jang-Ming Lee, Cheng-Chieh Lin, Ming-Tsang Wu, Relationship between genetic polymorphisms of alcohol and aldehyde dehydrogenases and esophageal squamous cell carcinoma risk in males World Journal of Gastroenterology. ,vol. 11, pp. 5103- 5108 ,(2005) , 10.3748/WJG.V11.I33.5103
Xiaocheng Wu, Vivien W. Chen, Bernado Ruiz, Patricia Andrews, L. Joseph Su, Pelayo Correa, Incidence of esophageal and gastric carcinomas among American Asians/Pacific Islanders, whites, and blacks: subsite and histology differences. Cancer. ,vol. 106, pp. 683- 692 ,(2006) , 10.1002/CNCR.21542
B M Ryan, R McManus, J S Daly, E Carton, P W N Keeling, J V Reynolds, D Kelleher, A common p73 polymorphism is associated with a reduced incidence of oesophageal carcinoma. British Journal of Cancer. ,vol. 85, pp. 1499- 1503 ,(2001) , 10.1054/BJOC.2001.2066
Qingyi Wei, Chunying Song, Deyin Xing, Dongxin Lin, Wen Tan, Methylenetetrahydrofolate reductase polymorphisms increase risk of esophageal squamous cell carcinoma in a Chinese population. Cancer Research. ,vol. 61, pp. 3272- 3275 ,(2001)
Thea M. Edwards, John Peterson Myers, Environmental exposures and gene regulation in disease etiology Ciencia & Saude Coletiva. ,vol. 13, pp. 269- 281 ,(2008) , 10.1590/S1413-81232008000100030
De-Yin Xing, Wen Tan, Nan Song, Dong-Xin Lin, Ser326Cys polymorphism in hOGG1 gene and risk of esophageal cancer in a Chinese population. International Journal of Cancer. ,vol. 95, pp. 140- 143 ,(2001) , 10.1002/1097-0215(20010520)95:3<140::AID-IJC1024>3.0.CO;2-2