Elevated Glycated Haemoglobin is a Strong Predictor of Mortality in Patients with Left Ventricular Systolic Dysfunction who are not receiving treatment for Diabetes Mellitus

摘要: Background: Glycated haemoglobin (HbA1c) is an indicator of average blood glucose concentrations over the preceding 3 months, simpler to perform than either a fasting or tolerance test and associated with worse prognosis in some clinical settings. However its relationship survival patients suspected heart failure has not been studied. Methods: Patients referred community-based clinic had comprehensive assessment including measurement HbA1c. For this analysis, DM initiation diabetic medication subsequent 12-months, which might influence HbA1c, were excluded. Findings: Of 970 non-diabetic between 2001-2004, median age was 72 years (range 25-96 years), 56% men, 45% left ventricular ejection fraction (LVEF) ≤45% 50% HbA1c >6% (upper reference limit). Amongst LVEF there abrupt increase mortality those >6.7% (n=68) compared ≤6.7% (n=368) (hazard ratio (HR): 2.4, p (HR 1.44, p=0.36 after adjustment). Interpretation: The may make it useful risk stratification tool could help improve management.