Roles of the KEAP1-NRF2 system in mammalian skin exposed to UV radiation

摘要: The KEAP1 (Kelch-like ECH-associated protein 1)-NRF2 (NF-E2-related factor 2) system controls the biochemical defense activity against agents toxic to mammals and responds exogenous endogenous stressors such as electrophilic oxidative substances, which can have destructive genotoxic effects on affected mammalian tissues. Although this be activated by various environmental stressors, it remains unclear whether ultraviolet radiation (UVR), is one of major that has inflammatory carcinogenic impacts human skin eyes, induces NRF2-dependent activity. Here, we review recent progress in study contributions NRF2 related factors protection UVR. KEAP1-NRF2 not always efficient responding UVR, especially short wavelengths UVC/UVB, indicating UVR a poor activator system. However, sustained activation appears suppress harmful chronic exposure, photoaging carcinogenesis skin, beneficial for from should noted prolonged strong may also adverse case UVR-induced carcinogenesis. We present working models describing mechanisms underlying involvement