Fish oil attenuates adrenergic overactivity without altering glucose metabolism during an oral glucose load in haemodialysis patients.

摘要: Haemodialysis patients display an increased cardiac mortality, which may be partly related to sympathoadrenal activity and insulin resistance. Fish oil decreases adrenal activation induced by mental stress has sensitizing effect in healthy subjects. Whole-body glucose metabolism after oral was studied eight haemodialysis before a 3-week fish supplementation (i.e. EPA + DHA at 1.8 g/d). Plasma fluxes were traced using [6,6- (2)H2]glucose infusion. Substrate oxidation determined indirect calorimetry. Each patient the basal state over 6 h following absorption of 1 g/kg load. Energy expenditure response re-increased last 2 experiment (P < 0.05), coincided with increase plasma catecholamines, especially epinephrine strongly suggesting overactivity. blunted both re-increase thermogenic concomitant epinephrine, but not norepinephrine, experiment. did alter either whole-body or substrate oxidation. These data show that patients, attenuates overactivity does modulate sensitivity.