Diacylglycerols Biosynthetic Intermediates and Lipid Second Messengers

摘要: Diacylglycerols (DAGs), long-recognized intermediates of lipid biosynthesis (Bell and Coleman, 1980), are now established second messengers crucial to both short- long-term regulation cellular function (Bishop Bell, 1989; Nishizuka, 1992). DAGs formed by hydrolysis membrane phospholipids through the action phospholipases. These intracellular events elicited in response highly diverse agents impinging on exterior surface a cell, such as growth factors, hormones, neurotransmitters. The location DAG formation, molecular species generated, time frame transients contribute versatility this lipid-derived messenger molecule. Extended elevations DAGs, particular derived from phosphatidylcholine, important cell transformation. Several functionally distinct pools exist, at plasma endoplasmic reticulum (ER). While ER is biosynthetic intermediate, for signaling. More recent studies indicate that signals also generated compartments, nucleus, where potential downstream effector molecules (protein kinase C or cytidylyltransferase) present. A functional distinction basis is, therefore, no longer immediately apparent. Rather, metabolic channeling emerging critical determinant their fate.