Repression of c-fos transcription is mediated through p67SRF bound to the SRE.

摘要: Human c-fos expression is subject to tight transcriptional control. The gene expressed at a high, constitutive level in some cell types and very low, but rapidly inducible many others. Induction of transcription by serum growth factors mediated the response element (SRE) which least two factors, p67SRF p62, bind. In this paper it demonstrated that low basal through bound SRE observed when binding prohibited. situation, an AP-1 consensus site adjacent permits transactivation gene. Thus three levels expression, induced, repressed constitutive, appear be determined occupation its interaction with other proteins.