Radiopharmaceutical pharmacokinetics in animals: critical considerations.

摘要: Since the advent of single photon emission computerized tomography (SPECT) and positron (PET) various chemical ligands have been labeled with radionuclides evaluated as tracer compounds in animal models to ascertain their suitability potential radiopharmaceuticals for humans. In absence a defined algorithm predict diagnostic efficacy radiopharmaceutical, any new radioligand has undergo preclinical evaluation even if it excellent vitro properties. Until now few studies produced pharmacokinetic data that could be translated from directly The purpose this review is highlight some critical aspects consider during development validation phase radiopharmaceutical. Interspecies differences knowledge physiological mechanism can become challenging drawbacks obtaining successful context, influence ABC transporters neuroimaging, effect plasma protein binding consequence anesthesia reference interspecies will discussed illustrative examples.