Non-Tuberculous Mycobacteria and the Performance of Interferon Gamma Release Assays in Denmark

摘要: Background The QuantiFERON-TB-Gold Test (QFT) is more specific than the Mantoux skin-test to discriminate between Mycobacterium tuberculosis (MTB) and non-tuberculous mycobacterial (NTM) infections. Here we study performance of QFT in patients with NTM disease. Methods From 2005 2011, nationwide patient data on positive cultures (n = 925) were combined results 16,133), both retrieved from International Reference Laboratory Mycobacteriology, Denmark. A total 112 infections had a performed, 53 definite disease, 10 possible disease 49 colonization. Results QFT was 8% (4/53) 40% (4/10) 31% (15/49) colonization. Positivity rate lowest among infected without RD1 region 4% (2/50). None 15 children MAC lymphadenitis QFT. Conclusion This one largest assessing IGRAs TB low-incidence setting. Our showed that holds potential MTB We found no IGRA test not sharing RD1-region resulting 100% specificity suggest child presenting cervical may be helpful distinguishing lymphadenitis.