Self-assembling amphiphilic block copolymer from renewable δ-decalactone and δ-dodecalactone

摘要: Aliphatic polyesters have many applications in the biomedical field due to their properties and facile degradation. They are commonly synthesized via ring opening polymerization (ROP) with metal-based catalysts, but as high temperatures needed products contain metal, organocatalysts now widely adopted polymerize them at room temperature while also ensuring short reaction times. Here, 1,7,7-triazabicyclo[4.4.0]-dec-5-ene is used less reactive renewably-derived lactones, namely δ-decalactone δ-dodecalactone. These monomers were chosen attempt of creating renewable highly lipophilic materials for drug delivery alternatives more traditional, non-renewable δ-valerolactone ɛ-caprolactone. A combination ROP living radical Reversible Addition-Fragmentation Chain Transfer proposed here synthesize grafted block copolymers. able self-assemble water, forming micelles where polyester core entrap a drug, thus making system good candidate delivery. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Chem.