Hantaviruses: a tale of two hemispheres.

摘要: Infectious febrile nephropathies, initially described as epidemics during military campaigns in Europe and Asia at the turn of 20(th) century, were eventually all unified under rubric hemorrhagic fever with renal syndrome (HFRS) ascribed to infection from rodent-borne hantaviruses. At end hantavirus pulmonary (HPS) was throughout Americas a consequence New World The epidemiology clinical manifestations these diseases are linked ecology their associated rodent hosts. Murine rodents (Old mice rats) severe forms HFRS Balkans due Hantaan, Dobrava, Seoul viruses. Hantaan virus causes an estimated 50-100,000 infections year China alone. Arvicoline (voles) mild form called nephropathia epidemica Puumala virus. Sigmodontine (New rats mice) approximately 200 HPS cases per caused by over dozen viruses mainly transmitted small-particle aerosols excreta, subsequent share cardiovascular shock prominent feature, although predominantly disease, while non-cardiogenic edema - hemorrhage involvement varies syndromes on basis subtypes. Efforts underway refine prevention strategies, understand pathogenesis shock, identify therapeutic modalities.