Adult High-Grade (Diffuse) Glioma

摘要: Malignant gliomas are the most common malignant brain tumors in adults. Although outcomes have improved over past decade with advent of new therapies, they remain aggressive and usually incurable. Our understanding genetic molecular changes that drive these has grown exponentially due to data gathered by Cancer Genome Atlas other groups, this is already being translated into therapeutic strategies. As we move further era personalized medicine, an will be more critical than ever developing individualized treatment In chapter, review our current biology tumors, as well treatments used or under investigation target particular biologic processes.