Implantable medical device having optical fiber for sensing electrical activity

摘要: An implantable medical device for optically sensing action potential signals in excitable body tissue. The includes an elongated tubular lead carrying optical fiber extending from a proximal end to distal position the at target site. additionally carries conduit dispensing voltage-sensitive fluorescent dye into tissue surrounding transmits excitation light cause fluoresce with varying intensity as transmembrane potentials of local cells vary due passing depolarization wavefronts. fluorescence signal generate or fiducial points use accurately measuring and characterizing electrical activity