作者: Vipin Sharma , Prince Sharma , Bhasker Mazumder , Aseem Bhatnagar , Thakuri Singh
DOI: 10.2174/1567201812666150212124054
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摘要: The microspheres of Isabgol husk were prepared by emulsification-crosslinking technique and the gastrointestinal transition behavior formulation was studied gamma scintigraphy. The impact different process variables such as amount glutaraldehyde, concentration husk and temperature on surface morphology and mucoadhesion. In vitro mucoadhesive testing of formulations performed determination zeta potential, mucus glycoprotein assay mucus adsorption isotherms. effect feeding retention in track (GIT) studied in albino rabbits scintigraphy study. results indicated formation observed by scanning electron microscopy. smooth round surfaces obtained increasing glutaraldehyde amount. positive potential all electrostatic interaction a mechanism mucoadhesion between GIT membranes surfaces. influence electrostatic interaction again ascertained when mucin equilibrium adsorption on preparations well fitness Langmuir Freundlich During scintigraphy, stability of 99m Tc-sodium pertechnetate found 98.82% at pH 6.8 96.78% 7.2, respectively. It the minimal leaching bound radionuclide from during scintigraphic images rabbits. retained even after 24 hrs oral administration. indicated the applicability mucilage development microspheres.