Interactions of Schiff base compounds and their coordination complexes with the drug cisplatin

摘要: There is a complex interplay between the structural and other physicochemical properties of new compounds molecules in living organisms. To understand mechanism interactions at molecular level, correlations selected their biological responses have to be examined. With this aim, paper, density functional theory (DFT) LMP2 calculations were carried out for 2-acetylpyridine-aminoguanidine ligand, L, its copper(II) complexes containing different monoanionic ligands. In addition, several parameters, most frequently used prediction drug-likeness compounds, calculated. The influence on effectiveness reference chemotherapeutic drug cisplatin was determined vitro, by comparison combination indices (CIs). earlier synthesized ligands L1 (bis(3-chloropyridazine-6-hydrazone)-2,6-diacetylpyridine) L2 (bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine) Co(III), Ni(II), Cu(II) Zn(II) complexes, respectively, also measured. L2, L3, as well showed with from strong antagonism L synergism 4-L1 4-L2. experimental results calculated parameters analyzed evaluate correlation measured interactions. thermal stability L·2HCl ligand four data correlated descriptors.