Fos and FRA protein expression in rat precerebellar structures during the Neurolab Space Mission.

摘要: Changes in gene expression were examined precerebellar structures during and after space flight. These included the inferior olive (IO), source of climbing fibers, lateral reticular nucleus (LRt) basilar pontine nuclei (PN), sources mossy fibers. We two immediate early products with different time courses expression: Fos, which persists only for a few (6-8)h activation FRA expression, lasts longer periods time, i.e. hours and/or days activation. Gravity effects on Fos evident vestibular visual areas IO, including dorsomedial cell column, beta subnucleus dorsal cap Kooy medial (which projects to flocculonodular lobe, area IO involved olivary control vestibulo-ocular reflex (VOR)). Gene also affected subnuclei A, B, C caudal part IO. regions do not receive afferents, but rather spinal are particularly vestibulospinal (VSR). observed LRt PN. suggest that sensory substitution, signals produced by subject's own activity replace normally provided macular stimulation, contributes recovery microgravity-related postural motor deficits. While no consistent increases occurred 24h launch, landing. hypothesize this asymmetrical pattern resulted from (i). tonic microgravity experienced launch counteracting increased phasic gravitational forces (ii). field landing potentiating The specificity these results is demonstrated an absence direct gravity-related changes other such as external cuneate nucleus, group X, column transmit exteroceptive proprioceptive thalamic somatosensory cerebral cortex. seen here interest view important role their projections play adaptive gain VOR VSR sustained visuo-vestibular neck-vestibular stimulation.