Gallbladder motility in children with celiac disease before and after gluten-free diet.

摘要: Background Gallbladder (GB) hypomotility has been reported in adults with celiac disease (CD), but there is no literature on GB dysfunction children CD. We aimed to study motility CD, before and after a gluten-free diet (GFD), using ultrasonography (USG) technetium-99 labeled mebrofenin hepatobiliary scintigraphy (HBS). Methods Children newly diagnosed CD were enrolled evaluated for ejection fraction (GBEF) HBS USG. Those reduced GBEF initial again 6 months of strict GFD the results compared. Results Of 50 (mean age 9±2.1 years, 54% boys), 16% (n=8) had low at baseline (19±13%). These significantly greater delay diagnosis compared those normal (6.5±2.0 vs. 2.3±1.2 P<0.001). A significant improvement was noted post (74±12%1 9±13%, also improved as assessed by USG parameters (P<0.001). The fasting volume decreased (5.7±1.4 10.2±2.6, P=0.002), percentage postprandial change (52±10.5% 24±16.5%, P=0.007) pre-GFD values. Orocecal transit time increased GBEF. Conclusions function impaired least reversible GFD. associated delayed may be part general gastrointestinal dysmotility.