Molecular Biology of Human Apolipoprotein B and Related Diseases
作者： Vassilis I. Zannis , M. Mahmood Hussain , Margarita Hadzopoulou-Cladaras , Anastasia Kouvatsi , Dimitris Kardassis
DOI: 10.1007/978-1-4613-0733-4_14
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摘要: Apolipoprotein B is the main protein component of LDL and comprises 23.8% particle (1,2). ApoB ligand for cellular recognition catabolism by receptor (1,3). The receptor-apoB interaction subsequent mediates clearance from plasma regulates cholesterol biosynthesis Early studies had shown that human rat apoB exist in two primary forms designated apoB-100 apoB-48 (4–12). seems to be important lipoprotein assembly secretion (14,15). Thus, absence apoR abetalipoproteinemia (16) or inhibition its synthesis cyclohexamide treatment cells (15) abolishes chylomicrons VLDL.
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