AraC in combination with a cytokine-secreting cell and methods of use thereof

作者: Karin Jooss , Betty Li , JianMin Lin , Melinda Van Roey , Eric Rimmer

DOI:

关键词:

摘要: The present invention provides improved method of cancer therapy in a mammal. More particularly, the is concerned with systems comprising cytosine arabinoside (AraC) and cytokine-expressing immunotherapy composition methods administering combination to patients order generate an immune response against provide treatment therapeutic efficacy that improvement relative administration AraC or alone as monotherapy.

参考文章(20)
Kyriaki Dunussi-Joannopoulos, Glenn Dranoff, Howard J. Weinstein, James L.M. Ferrara, Barbara E. Bierer, James M. Croop, Gene immunotherapy in murine acute myeloid leukemia: granulocyte-macrophage colony-stimulating factor tumor cell vaccines elicit more potent antitumor immunity compared with B7 family and other cytokine vaccines. Blood. ,vol. 91, pp. 222- 230 ,(1998) , 10.1182/BLOOD.V91.1.222
Karin Jooss, Thomas Du, Betty Li, Cytokine-expressing cancer immunotherapy combinations ,(2007)
Hyam I. Levitsky, Ivan Borrello, Universal GM-CSF expressing bystander human K562 cell line ,(2006)
Drew Pardoll, Richard C. Mulligan, Glenn Dranoff, Irradiated tumor cell vaccine engineered to express GM-CSF ,(1994)
William Nelson, Jonathan Simons, James McArthur, Margo Roberts, Dale Ando, Ju-Fay Chang, Cancer-associated antigens and methods of their identification and use ,(2005)
Karl Seeger, Manuel Schmidt, Burghardt Wittig, Hagen G. von Einsiedel, Florian Sack, Günter Henze, Sven A. König-Merediz, Dirk Buchwald, Renata Stripecke, Alexander Korte, Joachim Köchling, Protection of mice against Philadelphia chromosome-positive acute lymphoblastic leukemia by cell-based vaccination using nonviral, minimalistic expression vectors and immunomodulatory oligonucleotides. Clinical Cancer Research. ,vol. 9, pp. 3142- 3149 ,(2003)
Robert Zimmerman, Jeffrey L. Winkelhake, Combination therapy using interleukin-2 and tumor necrosis factor ,(1994)
Alfred E. Chang, Qiao Li, D. Keith Bishop, Daniel P. Normolle, Bruce D. Redman, Brian J. Nickoloff, Immunogenetic Therapy of Human Melanoma Utilizing Autologous Tumor Cells Transduced to Secrete Granulocyte-Macrophage Colony-Stimulating Factor Human Gene Therapy. ,vol. 11, pp. 839- 850 ,(2000) , 10.1089/10430340050015455