Relevance of Mitochondrial Functions and Plasticity in Tumor Biology

摘要: In this chapter we discuss the relevance of mitochondrial functions and plasticity in tumor biology. 1920, Otto Warburg first hypothesized that impairment is a leading cause cancer although he recognized existence oxidative tumors. Likewise, Weinhouse (1951) others found deficient respiration not an obligatory feature Peter Vaupel suggested 90s oxygenation rather than OXPHOS capacity was limiting factor energy production cancer. Recent studies now clearly indicate mitochondria are highly functional mice tumors field oncobioenergetics identified MYC, Oct1 RAS as pro-OXPHOS oncogenes. addition, cells adaptation to aglycemia, metabolic symbiosis between hypoxic non-hypoxic regions well reverse hypothesis support crucial role survival subclass Therefore, considered potential targets for anti-cancer therapy tentative strategies including bioenergetic profile characterization subsequent adapted modulation could be killing.