Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial

摘要: Apolipoprotein L1 gene ( APOL1 ) G1 and G2 coding variants are strongly associated with chronic kidney disease (CKD) in African Americans (AAs). Here association was tested baseline estimated glomerular filtration rate (eGFR), urine albumin:creatinine ratio (UACR), prevalent cardiovascular (CVD) 2571 AAs from the Systolic Blood Pressure Intervention Trial (SPRINT), a trial assessing effects of systolic blood pressure reduction on renal CVD outcomes. Logistic regression models that adjusted for potentially important confounders between risk clinical (myocardial infarction, coronary, or carotid artery revascularization) CKD (eGFR under 60ml/min per 1.73m 2 and/or UACR over 30mg/g). AA SPRINT participants were 45.3% female mean (median) age 64.3 (63) years, arterial 100.7 (100)mmHg, eGFR 76.3 (77.1) ml/min , 49.9 (9.2)mg/g, 8.2% had CVD. (recessive inheritance) positively (odds 1.37, 95% confidence interval 1.08–1.73) log slope β 0.33) negatively -3.58), all significant. not significantly (1.02, 0.82–1.27). Thus, data show mild but 1000mg/g.