Drug delivery to the CNS and polymeric nanoparticulate carriers
作者： Luca Costantino
DOI: 10.4155/FMC.10.249
关键词:
摘要: The delivery of drugs to the CNS is hampered by existence blood–brain barrier (BBB). Nowadays, medicinal chemists follow defined rules for development able cross BBB. At same time, parameters needed in order gain valuable estimates brain drug are well defined. Despite limits molecular weight that allow BBB, it was shown nanotech products, particular properly functionalized nanoparticles, spherical particles approximately 200 nm diameter, BBB after intravenous administration and act as carriers CNS. Moreover, peptides ligands receptors present on endothelium, or form conjugates with drugs, have been discovered started be studied targeting moieties nanoparticulate systems. This article will discuss results obtained so far field nanoparticle an...
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Luca Costantino, Giovanni Tosi, Barbara Ruozi, Lucia Bondioli, Maria Angela Vandelli, Flavio Forni, Chapter 3 - Colloidal systems for CNS drug delivery. Progress in Brain Research. ,vol. 180, pp. 35- 69 ,(2009) , 10.1016/S0079-6123(08)80003-9
Pilar Calvo, Bruno Gouritin, Hélène Chacun, Didier Desmaële, Jean D'Angelo, Jean‐Pierre Noel, Dominique Georgin, Elias Fattal, Jean P. Andreux, Patrick Couvreur, Long-circulating PEGylated polycyanoacrylate nanoparticles as new drug carrier for brain delivery. Pharmaceutical Research. ,vol. 18, pp. 1157- 1166 ,(2001) , 10.1023/A:1010931127745
Katalin Prokai-Tatrai, Laszlo Prokai, Modifying peptide properties by prodrug design for enhanced transport into the CNS. Progress in drug research. ,vol. 61, pp. 155- 188 ,(2003) , 10.1007/978-3-0348-8049-7_6
Peptide transport and delivery into the central nervous system Birkhäuser. ,(2003) , 10.1007/978-3-0348-8049-7
Jean‐Christophe Olivier, Laurence Fenart, Romain Chauvet, Claudine Pariat, Roméo Cecchelli, William Couet, Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity. Pharmaceutical Research. ,vol. 16, pp. 1836- 1842 ,(1999) , 10.1023/A:1018947208597
Marco van de Weert, Wim E Hennink, Wim Jiskoot, Protein instability in poly(lactic-co-glycolic acid) microparticles. Pharmaceutical Research. ,vol. 17, pp. 1159- 1167 ,(2000) , 10.1023/A:1026498209874
Jörg Kreuter, Peter Ramge, Valery Petrov, Stefan Hamm, Svetlana E. Gelperina, Britta Engelhardt, Renad Alyautdin, Hagen von Briesen, David J. Begley, Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles. Pharmaceutical Research. ,vol. 20, pp. 409- 416 ,(2003) , 10.1023/A:1022604120952
Paul R Lockman, Joanna Koziara, Karen E Roder, Jennifer Paulson, Thomas J Abbruscato, Russell J Mumper, David D Allen, In vivo and in vitro assessment of baseline blood-brain barrier parameters in the presence of novel nanoparticles Pharmaceutical Research. ,vol. 20, pp. 705- 713 ,(2003) , 10.1023/A:1023492015851
A K Kumagai, J B Eisenberg, W M Pardridge, Absorptive-mediated endocytosis of cationized albumin and a beta-endorphin-cationized albumin chimeric peptide by isolated brain capillaries. Model system of blood-brain barrier transport Journal of Biological Chemistry. ,vol. 262, pp. 15214- 15219 ,(1987) , 10.1016/S0021-9258(18)48160-4
Jörg Kreuter, Svetlana Gelperina, Use of nanoparticles for cerebral cancer. Tumori. ,vol. 94, pp. 271- 277 ,(2008) , 10.1700/346.4048