A Polymorphism Within the 3'UTR of NLRP3 is Associated with Susceptibility for Ischemic Stroke in Chinese Population.

摘要: Stroke was regarded as a severe disorder with high morbidity and mortality worldwide, ischemic stroke (IS) accounts for 85 to 90 % of new increased cases. Partial mechanisms were elucidated by genetic factors including genomic instability such single nucleotide polymorphism (SNP). Previous reports demonstrated that inflammation involved in IS, NLRP3 [nucleotide-binding domain (NOD)-like receptor protein 3], acting specific inflammatory gene, however, its function influence on IS not well clarified. In this study, case–control study 1102 patients 1610 healthy controls conducted investigate the association between susceptibility SNP (rs10754558) 3′UTR NLRP3. Logistic regression analysis showed heterozygote homozygote GG confer significantly risk CRC after controlling other covariates (adjusted OR = 1.52, 95 % C.I. 1.19–1.97, P = 0.002; adjusted OR = 2.22, 2.18–3.67, P < 0.001, respectively). Carriage G allele associated greatly developing disease (OR = 1.69, 1.31–1.83, P < 0.001). Stratification found hypertension had interaction rs10754558 modulate risk. Further vitro assay revealed can affect mRNA level NLRP3, suggesting possible functional significance. Our data suggested polymorphisms may Chinese population. Replication our studies populations further are required complete comprehension roles