Cathepsins B1 and B2 of Trichobilharzia SPP., Bird Schistosomes Causing Cercarial Dermatitis
作者： Martin Kašný , Libor Mikeš , Kateřina Dolečková , Vladimír Hampl , Jan Dvořák
DOI: 10.1007/978-1-4419-8414-2_9
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摘要: Trichobilharzia regenti and T. szidati are schistosomes that infect birds. although regenti/T. can only complete their life cycle in specific bird hosts (waterfowl), larvae—cercariae able to penetrate, transform then migrate as schistosomula nonspecific (e.g., mouse, man). Peptidases among the key molecules produced by these enable parasite invasion survival within host include cysteine peptidases such cathepsins B1 B2. These enzymes indispensable bio-catalysts a number of basal biological processes host-parasite interactions, e.g., tissue invasion/migration, nutrition immune evasion. Similar biochemical functional characteristics were observed for B2 (T. regenti, szidati) also homologs human (Schistosoma mansoni, S. japonicum). Therefore, data obtained research be exploited control search targets novel chemotherapeutic drugs vaccines.
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