Mechanisms of docosahexaenoic acid accretion in the fetal brain.

摘要: Docosahexaenoic acid (DHA, 22:6 n-3) is the major polyunsaturated fatty (PUFA) in adult mammalian brain. DHA an essential (FA) since it, or its short chain precursor, α-linolenic (LnA, 18:3 n-3), have to be obtained diet. Moreover, dietary n-3 FA deficiency associated with biochemical changes brain and disturbances vision other neurological parameters. Under normal nutritional conditions, fetal accumulation substantial, a “DHA accretion spurt” being demonstrated last period of gestation. This supported by maternal supply LnA, but selectivity probably placental function whose mechanism lately clarified. The gastrointestinal (G-I) tract may instrumental supplying under certain such as following intra-amniotic administration ethyl-docosahexaenoate (Et-DHA). In this pathway, supplied independently metabolism, liver apparently involved. G-I advantageous for cases maternal–placental insufficiency resulting intrauterine growth retardation. itself capable metabolizing LnA DHA, without participation liver, thus contributing own during one most crucial periods development. J. Neurosci. Res. 52:129–136, 1998. © 1998 Wiley-Liss, Inc.