Association between ACE Inhibitors and Acute Pancreatitis in the Elderly

作者: Roger MS Cheng , Muhammad Mamdani , Cynthia A Jackevicius , Karen Tu

DOI: 10.1345/APH.1C270

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摘要: BACKGROUND:Angiotensin-converting enzyme (ACE) inhibitor–induced acute pancreatitis has been described in various case reports and drug surveillance databases. At present, no epidemiologic studies examining the potential association between ACE inhibitors have identified.OBJECTIVE:To determine whether there is an inhibitor use pancreatic events (acute pancreatitis, surgery).METHODS:A retrospective cohort of Ontario residents aged ≥66 years was created using population-based administrative databases from January 1, 1994, through March 31, 2000. We compared incidence among new users (study group), warfarin (null baseline dihydropyridine calcium-channel antagonists (DCCAs; disease control group) multivariate Cox proportional hazard models.OUTCOME MEASURES:The primary outcome measure hospitalization with pancreatitis; secondary pancreati...

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