Reproducible Topical Staphylococcal Infection in Rats1

摘要: A topical infection model for the study of effectiveness antimicrobials was developed. Animals were laparotomized, sutured with braided silk, and inoculated a strain Staphylococcus aureus. The test organism phage typed, its antibiotic spectrum determined. Concentrations bacteria from 5 x 10(4) to 10(8) cells per incision produced large body wall stitch abscesses occasional drainage through skin. This laparotomy is readily reproducible can be used evaluation ability prevent S. aureus abscesses.