Novel Findings about Double-Loaded Curcumin-in-HPβcyclodextrin-in Liposomes: Effects on the Lipid Bilayer and Drug Release.

摘要: In this study, the encapsulation of curcumin (Cur) in “drug-in-cyclodextrin-in-liposomes (DCL)” by following double-loading technique (DL) was proposed, giving rise to DCL–DL. The aim analyze effect cyclodextrin (CD) on physicochemical, stability, and drug-release properties liposomes. After selecting didodecyldimethylammonium bromide (DDAB) as cationic lipid, DCL–DL formulated adding 2-hydroxypropyl-α/β/γ-CD (HPβCD)–Cur complexes into aqueous phase. A competitive cholesterol (Cho) for CD cavity found, so cholesteryl hemisuccinate (Chems) used. optimal composition bilayer obtained applying Taguchi methodology regression analysis. Vesicles showed a lower drug efficiency compared conventional liposomes (CL) CL containing HPβCD However, presence significantly increased vesicle deformability Cur antioxidant activity over time. addition, release profiles sustained after an initial burst effect, fitting Korsmeyer-Peppas kinetic model. Moreover, direct correlation between area under curve (AUC) dissolution flexibility obtained. It can be concluded that these “drug-in-cyclodextrin-in-deformable” may promising carrier increasing entrapment stability without compromising integrity liposome bilayer.