Microsatellite variation and recombination rate in the human genome.

摘要: Background (purifying) selection on deleterious mutations is expected to remove linked neutral from a population, resulting in positive correlation between recombination rate and levels of genetic variation, even for markers with high mutation rates. We tested this prediction the background model by comparing microsatellite polymorphism humans. Published data 28 unrelated Europeans were used estimate (number alleles, heterozygosity, variance allele size) loci throughout genome. Recombination rates estimated comparisons physical maps. First, we analyzed 61 chromosome 22, using complete sequence provide exact locations. These microsatellites showed no variation rate. then radiation-hybrid cytogenetic maps calculate varied more than one order magnitude, most chromosomes significant suppression near centromere. Genome-wide analyses provided evidence strong polymorphism, although at least 20 repeats suggested weak correlation. Comparisons lowest-recombination highest-recombination regions also revealed difference polymorphism. Together, these results indicate that not major determinant