Metabolism and disposition of 2,2',4,4',5-pentabromodiphenyl ether (BDE99) following a single or repeated administration to rats or mice.
作者： L.-J. Chen , E. H. Lebetkin , J. M. Sanders , L. T. Burka
DOI: 10.1080/00498250600674477
关键词:
摘要: The metabolism and disposition of 14C-labelled 2,2',4,4',5-pentabromodiphenyl ether (BDE99) were studied in F344 rats B6C3F1 mice. Approximately 85% a 1 micromol kg-1 oral dose was absorbed by male Within 24 h following doses ranging from 0.1 to 1000 rats, 39-47% the excreted faeces (including 16% unabsorbed), up 2% urine, 34-38% remained tissues, mostly adipose tissue. Mice more urine less than rats. Tissue accumulation observed repeated dosing Two dihydrohydroxy-S-glutathionyl two S-glutathionyl conjugates BDE99, 2,4,5-tribromophenol glucuronide, mono-hydroxylated BDE99 glucuronides, three tetrabromodiphenyl glucuronides identified rat bile. 2,4,5-Tribromophenol its glucuronide sulfate conjugates, urine. 2,4,5-Tribromophenol, one ether, characterized faeces. undergoes extensive does BDE47. Half 10 days as metabolites derived arene oxide intermediates.
informapharmascience.com参考文章(22)
Arnold Schecter, Marian Pavuk, Olaf Päpke, John Jake Ryan, Linda Birnbaum, Robin Rosen, Polybrominated diphenyl ethers (PBDEs) in U.S. mothers' milk. Environmental Health Perspectives. ,vol. 111, pp. 1723- 1729 ,(2003) , 10.1289/EHP.6466
H. Hakk, J. Huwe, M. Low, D. Rutherford, G. Larsen, Tissue disposition, excretion and metabolism of 2,2',4,4',6-pentabromodiphenyl ether (BDE-100) in male Sprague-Dawley rats. Xenobiotica. ,vol. 36, pp. 79- 94 ,(2002) , 10.1080/00498250500491675
J. M. Sanders, L.-J. Chen, E. H. Lebetkin, L. T. Burka, Metabolism and disposition of 2,2',4,4'- tetrabromodiphenyl ether following administration of single or multiple doses to rats and mice. Xenobiotica. ,vol. 36, pp. 103- 117 ,(2006) , 10.1080/00498250500485107
Michel Charbonneau, Josef Strasser, Edward A. Lock, Max J. Turner, James A. Swenberg, Involvement of reversible binding to α2u-globulin in 1,4-dichlorobenzene-induced nephrotoxicity Toxicology and Applied Pharmacology. ,vol. 99, pp. 122- 132 ,(1989) , 10.1016/0041-008X(89)90117-8
Tong Zhou, David G Ross, Michael J DeVito, Kevin M Crofton, Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats Toxicological Sciences. ,vol. 61, pp. 76- 82 ,(2001) , 10.1093/TOXSCI/61.1.76
Per Ola Darnerud, Sofia Risberg, Tissue localisation of tetra- and pentabromodiphenyl ether congeners (BDE-47, -85 and -99) in perinatal and adult C57BL mice Chemosphere. ,vol. 62, pp. 485- 493 ,(2006) , 10.1016/J.CHEMOSPHERE.2005.04.004
Andreas Sjödin, Richard S Jones, Jean-François Focant, Chester Lapeza, Richard Y Wang, Ernest E McGahee, Yalin Zhang, Wayman E Turner, Bill Slazyk, Larry L Needham, Donald G Patterson, Retrospective time-trend study of polybrominated diphenyl ether and polybrominated and polychlorinated biphenyl levels in human serum from the United States. Environmental Health Perspectives. ,vol. 112, pp. 654- 658 ,(2004) , 10.1289/EHP.112-1241957
L.S. Birnbaum, G.M. Decad, H.B. Matthews, Disposition and excretion of 2,3,7,8-tetrachlorodibenzofuran in the rat Toxicology and Applied Pharmacology. ,vol. 55, pp. 342- 352 ,(1980) , 10.1016/0041-008X(80)90096-4
M. Th. M. Tulp, G. Sundström, L. B. J. M. Martron, O. Hutzinger, Metabolism of Chlorodiphenyl Ethers and Irgasan® DP 300 Xenobiotica. ,vol. 9, pp. 65- 77 ,(1979) , 10.3109/00498257909038708
Cynthia A de Wit, An overview of brominated flame retardants in the environment. Chemosphere. ,vol. 46, pp. 583- 624 ,(2002) , 10.1016/S0045-6535(01)00225-9