Living inside the box: environmental effects on mouse models of human disease.

摘要: The impact of the laboratory environment on animal models human disease, particularly mouse, has recently come under intense scrutiny regarding both reproducibility such environments and their ability to accurately recapitulate elements environmental conditions. One common objection use mice in highly controlled facilities is that humans live much more diverse stressful environments, which affects expression characteristics disease phenotypes. In this Special Article, we review some known effects mouse phenotypes compare them with modify or, cases, have driven genetic adaptation. We conclude ‘boxes’ inhabited by common, but that, when attempting tease out phenotype, a and, importantly, well-characterized essential.