Mediation of suicide ideation in prolonged exposure therapy for posttraumatic stress disorder.

摘要: Abstract Background Evidence-based treatments for posttraumatic stress disorder (PTSD) are associated with reduction in suicidal ideation (SI), yet the mechanisms underlying this unclear. The current study investigated improvements PTSD, depression, and social support as potential mediators of change SI over time. Method Participants (N = 200) were active duty military personnel PTSD randomized to prolonged exposure therapy (PE) or present-centered (PCT). Using parallel mediation serial models, we examined relative influence on Results Consistent our hypotheses, lagged analyses revealed that depression was strongest mediator time PE PCT. Reductions subsequent reductions which SI. Treatment condition did not moderate relationship, a significant mediator. Conclusions In personnel, PCT PTSD. These results altered by treatment condition. Trial registration Clinicaltrials. gov identifier: NCT01049516. http://www.clinicaltrials.gov/show/NCT01049516 .