Interferons α/β and their receptors: place in the hierarchy of cytokines
作者： VLADIMIR P. ZAV'YALOV , GALINA A. ZAV'YALOVA
DOI: 10.1111/J.1699-0463.1997.TB00556.X
关键词:
摘要: Interferons alpha/beta (IFNs-alpha/beta) are the first cytokines to be produced by recombinant DNA technology. They regulate growth and differentiation, affecting cellular communication, signal transduction pathways immunological control. This review focuses on relationships between structure biological activities of IFNs-alpha/beta induced as a result specific interactions with different types polypeptide receptors well role glycolipids in modulation these activities. The discovery primary homology HuIFNs-alpha thymus hormone-thymosin alpha 1 (TM 1), experimental finding competition IFN-alpha TM for common reproduction reHuIFN-alpha 2 immunomodulating create basis therapeutics instead 1, potentiation vaccines reHuIFN-alpha. successful attempt at grafting HuIFN-alpha 2s 1-like site designed de novo protein albeferon is described. article also aims reviewing recent data concerning other their receptors. Their reciprocal structure-function taxonomy proposed. place hierarchy determined.
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