Characterization and zoonotic potential of endemic hepatitis E virus (HEV) strains in humans and animals in Hungary
作者： Gábor Reuter , Domonka Fodor , Petra Forgách , Andrea Kátai , György Szűcs
DOI: 10.1016/J.JCV.2009.01.008
关键词:
摘要: Abstract Background Hepatitis E virus (HEV) is a common cause of acute, fecally transmitted hepatitis in developing countries. Identification HEV indigenous human infection and domestic pig raising the possibility that also zoonosis. Objectives/study design Molecular detection epidemiology humans (South-East Hungary) with acute (pig, cattle) wild (boar roe-deer) animals (countrywide) by ELISA RT-PCR. Results Between 2001 2006, total 116 (9.6%) 1203 sera were positive IgM 13 (24.5%) 53 samples confirmed RT-PCR sequencing. Forty-two (27.3%) 154, 11 (34.4%) 32 9 (12.2%) 74 RT-PCR-positive from swine (feces: 22.7%; liver: 30.8%), roe-deer (liver) boar (liver), respectively. Except for an imported caused genotype 1, 19 sequences (human: 12, swine: 4, roe-deer: boar: 2) belong to 3 HEV. Genetically identical strains detected 2 other clusters. Conclusions endemic agent Hungary. Consumption raw or undercooked meat-products one possible sources infections. Cross-species potentially involves food-borne transmission route
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