Nicotinamide adenine dinucleotide (NAD+): essential redox metabolite, co-substrate and an anti-cancer and anti-ageing therapeutic target.

作者: Hollie B.S. Griffiths , Courtney Williams , Sarah J. King , Simon J. Allison

DOI: 10.1042/BST20190033

关键词:

摘要: … Current thinking: There has been a recent explosion of interest in NAD + because of its links to ageing and other diseases and its non-redox roles as a co-substrate for enzymes such as …

参考文章(121)
X. A. Cambronne, M. L. Stewart, D. Kim, A. M. Jones-Brunette, R. K. Morgan, D. L. Farrens, M. S. Cohen, R. H. Goodman, Biosensor reveals multiple sources for mitochondrial NAD Science. ,vol. 352, pp. 1474- 1477 ,(2016) , 10.1126/SCIENCE.AAD5168
Yuzheng Zhao, Aoxue Wang, Yejun Zou, Ni Su, Joseph Loscalzo, Yi Yang, In vivo monitoring of cellular energy metabolism using SoNar, a highly responsive sensor for NAD + /NADH redox state Nature Protocols. ,vol. 11, pp. 1345- 1359 ,(2016) , 10.1038/NPROT.2016.074
Arvindhan Nagarajan, Parmanand Malvi, Narendra Wajapeyee, Oncogene-directed alterations in cancer cell metabolism. Trends in cancer. ,vol. 2, pp. 365- 377 ,(2016) , 10.1016/J.TRECAN.2016.06.002
Michael S. Bonkowski, David A. Sinclair, Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds. Nature Reviews Molecular Cell Biology. ,vol. 17, pp. 679- 690 ,(2016) , 10.1038/NRM.2016.93
Samuel A. J. Trammell, Mark S. Schmidt, Benjamin J. Weidemann, Philip Redpath, Frank Jaksch, Ryan W. Dellinger, Zhonggang Li, E. Dale Abel, Marie E. Migaud, Charles Brenner, Nicotinamide riboside is uniquely and orally bioavailable in mice and humans Nature Communications. ,vol. 7, pp. 12948- ,(2016) , 10.1038/NCOMMS12948
Amit D. Gujar, Son Le, Diane D. Mao, David Y. A. Dadey, Alice Turski, Yo Sasaki, Diane Aum, Jingqin Luo, Sonika Dahiya, Liya Yuan, Keith M. Rich, Jeffrey Milbrandt, Dennis E. Hallahan, Hiroko Yano, David D. Tran, Albert H. Kim, An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma Proceedings of the National Academy of Sciences of the United States of America. ,vol. 113, pp. 201610921- ,(2016) , 10.1073/PNAS.1610921114
Federico Carbone, Luca Liberale, Aldo Bonaventura, Alessandra Vecchiè, Matteo Casula, Michele Cea, Fiammetta Monacelli, Irene Caffa, Santina Bruzzone, Fabrizio Montecucco, Alessio Nencioni, Regulation and Function of Extracellular Nicotinamide Phosphoribosyltransferase/Visfatin. Comprehensive Physiology. ,vol. 7, pp. 603- 621 ,(2017) , 10.1002/CPHY.C160029
Kow Essuman, Daniel W. Summers, Yo Sasaki, Xianrong Mao, Aaron DiAntonio, Jeffrey Milbrandt, The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration Neuron. ,vol. 93, pp. 1334- 1343 ,(2017) , 10.1016/J.NEURON.2017.02.022
Li Q Zhang, Leon Van Haandel, Min Xiong, Peixin Huang, Daniel P Heruth, Charlie Bi, Roger Gaedigk, Xun Jiang, Ding-You Li, Gerald Wyckoff, Dmitry N Grigoryev, Li Gao, Linheng Li, Min Wu, J Steven Leeder, Shui Qing Ye, None, Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase Cell Death and Disease. ,vol. 8, pp. 2705- ,(2017) , 10.1038/CDDIS.2017.132
Antonio Lucena-Cacace, Daniel Otero-Albiol, Manuel P. Jiménez-García, Javier Peinado-Serrano, Amancio Carnero, NAMPT overexpression induces cancer stemness and defines a novel tumor signature for glioma prognosis Oncotarget. ,vol. 8, pp. 99514- 99530 ,(2017) , 10.18632/ONCOTARGET.20577