Correlates of Osteopenia in Patients With Cystic Fibrosis

摘要: Objective. As the expected survival improves for individuals with cystic fibrosis, these face myriad medical complications. The goals of this study were to examine prevalence osteopenia in children and adults fibrosis elucidate risk factors associated deficits bone mineral. Methodology. We compared mineral levels 49 patients (30 female 19 male) ages 8 through 48 years those age- sex-matched control subjects. Lumbar spine, femoral neck, whole-body measured by dual-energy radiographic absorptiometry expressed terms content, areal density (BMD), apparent (BMAD), which corrects differences size. Clinical variables evaluated as potential correlates Results. Patients had significantly less than did subjects at all sites using expressions mass. Mean BMD z scores -1.7 (lumbar spine), -1.9 (femoral neck), -1.2 (whole body). BMAD also low age gender. Twenty-six (8 adolescents) significant according their scores; 14 45 (5 available values one or more sites. Age, pubertal stage, body mass, caloric expenditure, illness severity, glucocorticoid therapy, gonadal function predicted status. Serum parathyroid hormone calcium, carbohydrate intake, weight-bearing activity limited predictive value. Daily calcium intake transmembrane regulator genotype not predict Conclusions. Osteopenia is common suggesting that inadequate accretion well increased loss contribute observed. Several clinical seem deficits.