Endothelin Receptors in the Failing and Nonfailing Human Heart
作者： Klaus Pönicke , Magdalene Vogelsang , Moritz Heinroth , Karin Becker , Oliver Zolk
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摘要: Background—In patients with chronic heart failure (CHF), plasma endothelin-1 (ET-1) levels are increased. We studied whether the cardiac ET-receptor system is altered in CHF patients. Methods and Results—We assessed ET-evoked inositol phosphate (IP) formation slices from right atria left ventricles 6 potential transplant donors (NFH) 15 end-stage CHF; membranes same tissues, we ET-induced inhibition of isoprenaline- forskolin-stimulated adenylyl cyclase density. ET (10−9 to 10−6 mol/L, ET-1 >>> ET-3) increased IP through ETA-receptor stimulation a concentration-dependent manner; no difference potency or efficacy between NFH hearts was observed. (10−10 mol/L), via stimulation, inhibited but not ventricles, whereas carbachol both tissues; aga...
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