Primary hyperparathyroidism is common among postmenopausal women. Identification of genetic risk factors can contribute to individualized treatment

摘要: Primary hyperparathyroidism (pHPT) is commonly seen in postmenopausal women. Along with the clinical characterisation of disease, studies molecular genetics have contributed to increased understanding etiology pHPT. Genetic association revealed that certain vitamin D receptor polymorphisms relate development sporadic A new type familial pHPT was recently discovered. Studies parathyroid adenomas demonstrated tumor suppressor gene MEN1 and oncogene cyclinD1 are importance for tumorigenesis.