Cinacalcet Reduces Serum Calcium Concentrations in Patients with Intractable Primary Hyperparathyroidism

摘要: Context: Patients with persistent primary hyperparathyroidism (PHPT) after parathyroidectomy or contraindications to often require chronic treatment for hypercalcemia. Objective: The objective of the study was assess ability calcimimetic, cinacalcet, reduce serum calcium in patients intractable PHPT. Design: This an open-label, single-arm comprising a titration phase variable duration (2–16 wk) and maintenance up 136 wk. Setting: conducted at 23 centers Europe, United States, Canada. Patients: included 17 PHPT greater than 12.5 mg/dl (3.1 mmol/liter). Intervention: During phase, cinacalcet dosages were titrated every 2 wk (30 mg twice daily 90 four times daily) 16 until 10 less (2.5 If increased during additional increases dose perm...