Potential of soluble CD26 as a serum marker for colorectal cancer detection.

摘要: Colorectal cancer is characterized by a low survival rate even though the basis for colon development, which involves evolution of adenomas to carcinoma, known. Moreover, mortality rates continue rise in economically transitioning countries although there opportunity intervene natural history adenoma–cancer sequence through risk factors, screening, and treatment. Screening particular accounted most decline colorectal achieved USA during period 1975-2000. Patients show better prognosis when neoplasm diagnosed early. Among variety screening strategies, methods range from invasive costly procedures such as colonoscopy more low-cost non-invasive tests fecal occult blood test (guaiac immunochemical). As biological serum marker would be great benefit because performance test, several biomarkers, including cytologic assays, DNA mRNA, soluble proteins, have been studied. We found that CD26 (sCD26) concentration diminished patients compared healthy donors, suggesting potential utility sCD26 immunochemical detection early diagnosis. originates plasma membrane lacking its transmembrane cytoplasmic domains. Some 90%–95% has associated with dipeptidyl peptidase IV (DPP-IV) activity. DPP-IV, assigned cluster, pleiotropic enzyme expressed mainly on epithelial cells lymphocytes. Our studies intended validate this population detect advanced are reviewed here.