Chronic idiopathic urticaria for the generalist.

摘要: Abstract Chronic idiopathic urticaria (CIU) manifests as frequently occurring, short-lived wheals, surrounded by a bright-red flare, and often accompanied angioedema. The cause of CIU is undefined its diagnosis requires exclusion other conditions with somewhat similar symptoms. Recent evidence has indicated that IgG autoantibodies directed against high-affinity IgE receptors (FcϵRI) may be involved in the pathophysiology CIU. Following release mast cell or basophil-derived histamine, this mediator binds to H 1 2 receptors, leading vasodilatation increased vascular permeability. Individuals unable conduct normal daily activities; therefore, prompt initiation effective treatment essential. General management patients should include avoidance substances likely trigger intensify episodes. Treatment antihistamines mainstay pharmacotherapy for Selection antihistamine therapy based on following key properties: (1) proven clinical efficacy providing high rate symptom improvement, (2) rapid onset action long-lasting response, (3) an excellent safety profile degree tolerability. benefit some second-generation limited sedation, drug–drug interactions, variable therapeutic response. -receptor antagonist desloratadine new, once-daily option potent nonsedating, low potential interactions. Desloratadine been shown effectively safely reduce pruritus number size hives CIU, improvements quality life.