Analysis of Intestinal Transporters

摘要: Intestinal transporters are involved in both influx (absorption) and efflux (exsorption) of various drugs thereby affect the bioavailability those drugs. tissues heterogeneous, exhibiting regional variations physiology transporter expression, as well having highly variable intestinal luminal contents. Furthermore, absorption may proceed via plural mechanisms, such simple diffusion, carrier-mediated transport, paracellular parallel. Accordingly, it is not necessarily easy to identify mechanism(s) particular However, by employing combinations several experimental methods, some drug exsorption have been found. P-glycoprotein BCRP key that serve limit As for transporters, picture has yet fully clarified, but PEPT1 OATP demonstrated contribute absorption, they expected be available target molecules improving orally administered This chapter focuses on current understanding especially less-studied absorptive methods analyze transport processes.