Prostate cancer epigenetics and its clinical implications.

摘要: Normal cells have a level of epigenetic programming that is superimposed on the genetic code to establish and maintain their cell identity phenotypes. This can be thought as architecture, sort cityscape, built upon underlying landscape. The encoded by complex set chemical marks DNA, histone proteins in nucleosomes, numerous context-specific RNA, protein interactions all regulate structure, organization, function genome given cell. It becoming increasingly evident abnormalities both landscape cityscape cooperate drive carcinogenesis disease progression. Large-scale cancer sequencing studies revealed mutations genes encoding enzymatic machinery for shaping are among most common observed human cancers, including prostate cancer. Interestingly, although constellation quite heterogeneous from person person, there alterations appear highly recurrent, nearly universal type, recurrent nature these exploited development biomarkers detection risk stratification targets therapeutic intervention. Here, we explore basic principles processes normal discuss potential clinical implications with regards biomarker therapy.