Distribution and molecular characterization of Porphyromonas gulae carrying a new fimA genotype

摘要: Porphyromonas gulae is a gram-negative black-pigmented anaerobe which known to be pathogen for periodontitis in dogs. Approximately 41kDa filamentous appendages on the cell surface (FimA) encoded by fimA gene are regarded as important factors associated with periodontitis. The genotype was classified into two major types and strains type B were shown more virulent than those A. In present study, we characterized strain novel designated it C. putative amino acid sequence similar IV of gingivalis, human Analyses using an oral squamous carcinoma line derived from tongue primary lesions revealed that C inhibited proliferation scratch closure A strains. addition, experiments mouse abscess model demonstrated could induce much higher systemic inflammation when compared other genotypes. Furthermore, molecular analyses swab specimens collected dogs detection frequencies P. group significantly periodontally healthy group. These results suggest FimA diverse virulence highest identification possible useful marker identifying at high risk developing