Human genetics of infectious diseases: between proof of principle and paradigm

摘要: The observation that only a fraction of individuals infected by infectious agents develop clinical disease raises fundamental questions about the actual pathogenesis diseases. Epidemiological and experimental evidence is accumulating to suggest human genetics plays major role in this process. As we discuss here, predisposition diseases seems cover continuous spectrum from monogenic polygenic inheritance. Although many studies have provided proof principle may result various types inborn errors immunity, genetic determinism most patients remains unclear. However, future, are likely establish new paradigm for