Triterpenoid saponins and C-glycosyl flavones from stem bark of Erythrina abyssinica Lam and their cytotoxic effects.

摘要: ABSTRACT Six new compounds including two oleanane-type triterpenoid saponins ( 1 , 2 ) and four C -glycosyl flavones 3 – 6 ), along with a known saponin 7 three di- 8 10 glycosyl auronol 11 were isolated from the stem bark of Erythrina abyssinica Lam. The structures compounds, identified as 3- O -[α-l-rhamnopyranosyl-(1 → 2)-β-d-galactopyranosyl-(1 → 2)-β-d-glucuronopyranosyl]-22- -β-d-glucopyranosyl sophoradiol -[α-l-rhamnopyranosyl-(1 → 2)-β-d-glucopyranosyl-(1 → 2)-β-d-glucuronopyranosyl]-22- -β- d -glucopyranosyl 6- -β-glucopyranosyl-8- -β-quinovopyranosyl apigenin -β-quinovopyranosyl-8- -β-glucopyranosyl 4 8- -[6″- -α-l-rhamnopyranosyl-(1‴ → 6″)]-β-glucopyranosyl 7,4′-dihydroxyflavone 5 -β-d-xylopyranosyl-(1‴ → 6″)]-β-glucopyranosyl determined by comprehensive spectroscopic analysis, 1D 2D NMR techniques, mass spectrometry acid hydrolysis. These together evaluated for their cytotoxic activity against MCF-7 (estrogen dependent) MDA-MB-231 independent) cell lines. exhibited highest among tested exerting selective inhibitory effect proliferation cells, lower IC 50 value (12.90 μM) than that positive control, resveratrol (13.91 μM). Structure–activity relationship these is also discussed.