The outer vestibule of the Na+ channel-toxin receptor and modulator of permeation as well as gating
作者： René Cervenka , Touran Zarrabi , Peter Lukacs , Hannes Todt
DOI: 10.3390/MD8041373
关键词:
摘要: The outer vestibule of voltage-gated Na+ channels is formed by extracellular loops connecting the S5 and S6 segments all four domains (“P-loops”), which fold back into membrane. Classically, this structure has been implicated in control ion permeation toxin blockage. However, conformational changes may also result alterations gating, as suggested several P-loop mutations that gave rise to gating changes. Moreover, partial pore block mutated toxins reverse induced mutations. Therefore, bind can be used modulate channel gating.
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