Antibacterial Activity of the Pancreatic Fluid

摘要: The antibacterial activity of canine pancreatic fluid was investigated in an attempt to understand the resistance this organ, when intact, ascending bacterial infections. demonstrated bactericidal against Escherichia coli, Shigella species, Salmonella and Klebsiella pneumoniae; bacteriostatic coagulase-positive coagulase-negative staphylococci Pseudomonas aeruginosa; f ungistatic Candida albicans. There no demonstrable Bacteroides fragilis Streptococcus faecalis. dialyzable pH dependent, but independent heat, several digestive enzymes, inoculum. Electron micrographs coli exposed did not demonstrate changes cell wall. Tracer studies susceptible bacteria decreased leucine uptake briefly fluid. found by column chromatography be a small molecular peptide. It is likely that factors protect pancreas from infections operate along with other homeostasis upper bowel flora.