Chapter 4 Rubella Vaccine

摘要: Publisher Summary To develop a vaccine of Rubella virus, researchers approached the issue in two different ways: inactivated or killed live-attenuated virus vaccine. Using approach rubella DNAs were constructed and evaluated mouse model. Equivalent antibody responses mice infected with natural DNA vaccines documented persistence titers for 7 months. If developed these nonreplicating might be indicated special circumstances, such as vaccination pregnant women. RA 27/3 is by approach. The that served basis was isolated from 27th fetus. cultured kidney tissue third fetal explant. supernatant fluid cells directly planted on WI-38 human diploid cells. Attenuation accomplished serial passage at low temperatures (cold adaptation). produced between 25th 33rd After development licensure initial globally, additional have been licensed various geographic locations.