Electrochemical Acetylcholinesterase Biosensor Based on Polylactide–Nanosilver Composite for the Determination of Anti-dementia Drugs
作者： Rezeda V. Shamagsumova , Olga Yu. Efimova , Vladimir V. Gorbatchuk , Vladimir G. Evtugyn , Ivan I. Stoikov
DOI: 10.1080/00032719.2018.1557202
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摘要: AbstractA new acetylcholinesterase biosensor has been developed for the determination of anticholinesterase drugs applied neurodegenerative disease treatment. For this purpose, silver nanosendrites were deposited by potentiostatic electrolysis on a glassy carbon electrode covered with oligolactides cross-linked p-tert-butylthiacliax[4]arene core in cone, partial and 1,3-alternate configurations. The roles macrocycle configuration conditions depostion characterized optimal selected subsequent immobilization acetylcholinesterase. Silver nanoparticles provide higher response at low working potential (0.05 V) due to electrostatic accumulation ions prevention their leaching after reoxidation. allows 10−12 – 10−7 M donepezil, berberine, huperzine A within 20-30 s relative decay current related oxidation thiocholine formed enzymatic reaction. T...
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